Sure enough, overall mean urinary citrate was raised for the mice fed K-cit (K-cit, 182±step 3
cuatro mg/d versus KCl, 110±2.7 mg/d; P<0.001) ( Table 1 ). K-cit increased the mean overall urinary pH (K-cit, 7.51±0.04 versus KCl, 6.71±0.05; P<0.001). K-cit reduced mean overall urinary NH4 (K-cit, 0.25±0.01 mmol/d versus KCl, 0.41±0.01 mmol/d; P<0.001). K-cit increased the mean overall urinary sulfate (K-cit, 1.08±0.02 mEq/d versus KCl, 0.86±0.02 mEq/d; P<0.001). Each of these changes was present at each time point. Overall mean urinary uric acid excretion did not differ (K-cit, 1.6±0.1 mg/d versus KCl, 2.0±0.2 mg/d; P=NS).
Desk 1.
Urinary citrate, pH and sulfate were increased while NH4, chloride, sodium and K were the same or decreased with K-cit compared to KCl
Opinions is indicated just like the indicate±SEM. Urine was accumulated to have twenty four hours on 6, a dozen, and you can 18 wk to decide solute profile because explained from the To the point Methods.
K-cit resulted in a slightly lower overall mean urinary sodium (K-cit, 2.16±0.03 mmol/d versus KCl, 2.36±0.04; P<0.001), which was significant at 6 and 18 weeks but not at 12 weeks ( Table 1 ). K-cit resulted in a slightly but significantly lower mean overall urinary K (K-cit, 4.8±0.04 mmol/d versus KCl, 5.3±0.08 mmol/d; P<0.001) that was significant at each time period. As expected, the rats receiving K-cit excreted less chloride than the rats receiving KCl (K-cit, 2.2±0.07 mEq/d versus KCl, 6.4±0.15 mEq/d; P<0.001), which was significant at each 6-week time period. K-cit did not alter the overall mean urine volume (K-cit, 47.3±1.6 ml/d versus KCl, 53.0±2.7 ml/d; P=NS) or the overall mean urinary creatinine (K-cit, ±0.17 mg/d versus KCl, ±0.22 mg/d; P=NS).
Pee Supersaturation
K-cit led to a significant increase in the urinary supersaturation with respect to both CaP (K-cit, 8.5±0.6 versus KCl, 4.9±0.2; P<0.001) and CaOx (K-cit, 9.8±0.5 versus KCl, 5.5±0.2; P<0.001) and a reduction of supersaturation with respect to uric acid (K-cit, 0.003±0.0005 versus KCl, 0.022±0.003; P<0.001) ( Figure 2 ). Continue Reading
